Tiere mit unzureichender expression der uridin-phosphorylase

Animaux presentant une expression insuffisante d'uridine phosphorylase

Animals with insufficient expression of uridine phosphorylase


Non-human animals deficient in a function of a uridine phosphorylase gene on a chromosome, and their offspring. These non-human animals and their offspring make it possible to elucidate pathologic functions and activities of nucleic acid dysbolism and the like and also to predict utility of pyridine nucleoside antimetabolites in human, and are useful as experimental animals.




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Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    WO-0160985-A2August 23, 2001Yale UniversityCompositions, methods and kits relating to uridine phosphorylase gene mutations

NO-Patent Citations (2)

    CAO D ET AL: "Construction of uridine phosphorylase knockout cell lines: Effect on pyrimidine pools and 5-fluorouracil antitumor activity" PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 40, March 1999 (1999-03), page 8 XP001064199
    See also references of WO 0143539A1

Cited By (0)

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